Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 8/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5413202 | 0.82 | STK17A (0.53) | STK17AGSK3BLRRK2MEN1CYP1A2 | |
| SCHEMBL5408180 | 0.81 | STK17A (0.66) | STK17AGSK3BLRRK2MEN1CYP1A2 | |
| SCHEMBL5414030 | 0.80 | GSK3B (0.54) | STK17AGSK3BMEN1CYP1A2CYP3A4 | |
| SCHEMBL5410531 | 0.80 | LRRK2 (0.44) | STK17ALRRK2NUDT1 | |
| SCHEMBL5413172 | 0.80 | GSK3B (0.51) | STK17AGSK3BLRRK2MEN1CYP1A2 | |
| SCHEMBL5413375 | 0.79 | PRKCQ (0.64) | STK17AGSK3BLRRK2MEN1CYP1A2 | |
| SCHEMBL5418647 | 0.79 | IGF1R (0.59) | GSK3BLRRK2MEN1CYP1A2CYP3A4 | |
| SCHEMBL5413361 | 0.77 | GLO1 (0.53) | LRRK2NUDT1 | |
| SCHEMBL5416094 | 0.77 | NUDT1 (0.45) | LRRK2NUDT1CNR2 | |
| SCHEMBL5405521 | 0.76 | GSK3B (0.61) | STK17AGSK3BMEN1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166599-B2 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2007-01-23 | — | — | US | disclosed |
| US-20050090486-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-04-28 | — | — | US | disclosed |
| US-20030134838-A1 | Trisubstituted pyrimidines | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134838-A1 | Trisubstituted pyrimidines | APP, PSEN1, BACE1 | STK17A 3301/4885GSK3B 1515/4885LRRK2 619/4885 |
| US-20050090486-A1 | Trisubstituted pyrimidines | APP, BACE1, PSEN1 | STK17A 3456/4885GSK3B 790/4885LRRK2 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.