Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943774 | 0.84 | FAAH (0.42) | FAAHLMNA | |
| SCHEMBL9693497 | 0.75 | ALDH1A1 (0.33) | TSHR | |
| SCHEMBL4705936 | 0.73 | FAAH (0.49) | TRPV1FAAHTSHRCNR1CNR2 | |
| SCHEMBL4708106 | 0.73 | FAAH (0.49) | TRPV1FAAHTSHRCNR1CNR2 | |
| SCHEMBL4705933 | 0.73 | FAAH (0.49) | TRPV1FAAHTSHRCNR1CNR2 | |
| SCHEMBL8568034 | 0.72 | TRPV1 (0.37) | TRPV1FAAHTSHRCNR1CNR2 | |
| SCHEMBL4948688 | 0.71 | FAAH (0.41) | FAAHTSHRCNR1CNR2LMNA | |
| SCHEMBL11616887 | 0.69 | GLS2 (0.43) | FAAHTSHR | |
| SCHEMBL10880030 | 0.68 | FAAH (0.47) | FAAHTSHR | |
| SCHEMBL11548667 | 0.68 | FAAH (0.47) | FAAHTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546230-B1 | COMPOUNDS CONTAINING SILICON-CONTAINING GROUPS, MEDICAL DEVICES AND METHODS | MEDTRONIC INC (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7365134-B2 | Compounds containing silicon-containing groups, medical devices, and methods | MEDTRONIC, INC (US) | 2008-04-29 | — | — | US | disclosed |
| US-6984700-B2 | Compounds containing silicon-containing groups, medical devices, and methods | MEDTRONIC, INC. (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050228161-A1 | Reacting an organosilicon compound with hydroxy or amine end groups with diisocyanate; biostable polymers, particularly polyurethanes suitable for use as insulation on pacing leads | MEDTRONIC, INC. (US) | 2005-10-13 | — | — | US | disclosed |
| EP-1546230-A1 | COMPOUNDS CONTAINING SILICON-CONTAINING GROUPS, MEDICAL DEVICES, AND METHODS | Medtronic, Inc. (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004026935-A1 | COMPOUNDS CONTAINING SILICON-CONTAINING GROUPS, MEDICAL DEVICES, AND METHODS | MEDTRONIC, INC. (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040054080-A1 | Compounds containing silicon-containing groups, medical devices, and methods | MEDTRONIC, INC. | 2004-03-18 | — | — | US | disclosed |