Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5418794 | 0.91 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1HRH1HRH3MAPT | |
| SCHEMBL5414707 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1MAPTADORA2AADORA2B | |
| SCHEMBL5414212 | 0.74 | MAPT (0.46) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL5411916 | 0.72 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL5418577 | 0.71 | MAPT (0.55) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL5417394 | 0.71 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1MAPTHTTPOLB | |
| SCHEMBL1196 | 0.71 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MAPTHTTPOLB | |
| SCHEMBL28038421 | 0.70 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL5422728 | 0.69 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1MAPTHTTLMNA | |
| SCHEMBL5411887 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2ALDH1A1MAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7232816-B2 | Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them | PFIZER, INC. (US) | 2007-06-19 | — | — | US | disclosed |
| US-6962912-B2 | Substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them | WARNER-LAMBERT LLC (US) | 2005-11-08 | — | — | US | disclosed |
| US-20050130957-A1 | Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them | PFIZER INC. | 2005-06-16 | — | — | US | disclosed |
| EP-1248787-B1 | NOVEL SUBTITUTED PYRAZOLO[4,3-e]DIAZEPINES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, USE AS MEDICINAL PRODUCTS AND PROCESSES FOR PREPARING THEM | WARNER LAMBERT CO (US) | 2004-10-06 | — | — | EP | disclosed |
| US-20030171364-A1 | Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them | BURNOUF CATHERINE (FR) | 2003-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130957-A1 | Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medical products and processes for preparing them | ADRA2C, CYP3A5, CYP2C19 | SMN1; SMN2 3412/4885ALDH1A1 1668/4885HRH1 56/4885 |
| US-20030171364-A1 | Novel substituted pyrazolo[4,3-e]diazepines, pharmaceutical compositions containing them, use as medicinal products and processes for preparing them | CYP3A5, THPO, CYP3A4 | SMN1; SMN2 3665/4885ALDH1A1 1481/4885HRH1 116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.