Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.51 |
| ▸ | USP2 | O75604 | 8/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.51 |
| ▸ | CTSG | P08311 | 2/20 | 0.50 |
| ▸ | CMA1 | P23946 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 7/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431071 | 0.95 | CYP3A4 (0.46) | CYP3A4USP2CYP1A2CYP2D6CTSG | |
| SCHEMBL5421659 | 0.90 | MAPT (0.44) | CYP3A4USP2CYP1A2CYP2D6CTSG | |
| SCHEMBL5421695 | 0.90 | USP2 (0.45) | CYP3A4USP2CYP1A2CYP2D6CTSG | |
| SCHEMBL5427031 | 0.89 | CYP3A4 (0.55) | CYP3A4USP2CYP1A2CYP2D6TSHR | |
| SCHEMBL5425174 | 0.89 | CTSG (0.53) | CYP3A4USP2CYP1A2CYP2D6CTSG | |
| SCHEMBL5428147 | 0.87 | CCR6 (0.48) | CYP3A4USP2CYP1A2CYP2D6TSHR | |
| SCHEMBL5434972 | 0.87 | NR3C1 (0.50) | CYP3A4USP2CYP1A2CYP2D6TSHR | |
| SCHEMBL5429580 | 0.87 | CCR6 (0.44) | CYP3A4USP2CYP1A2CYP2D6TSHR | |
| SCHEMBL5429999 | 0.87 | CCR6 (0.48) | CYP3A4USP2CYP1A2CYP2D6TSHR | |
| SCHEMBL5429590 | 0.87 | CYP3A4 (0.41) | CYP3A4USP2CYP1A2CYP2D6CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | ONO PHARMACEUTICAL CO., LTD. | 2007-11-29 | — | — | US | claimed |
| EP-1683797-A1 | HETEROCYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-26 | — | — | EP | claimed |
| US-20070275990-A1 | Heterocyclic Spiro Compound | ONO PHARMACEUTICAL CO., LTD. | 2007-11-29 | — | — | US | disclosed |
| EP-1683797-A1 | HETEROCYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | NR3C2, CBR1, CBR3 | CYP3A4 888/4885USP2 4846/4885CYP1A2 909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.