Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 | P31639 | 4/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318090 | 0.89 | TUBB4A (0.37) | MAPTMAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10109140 | 0.89 | TUBB4A (0.37) | MAPTMAPK1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL318057 | 0.73 | MAP2K3 (0.40) | MEN1KMT2AMAPK1 | |
| SCHEMBL318433 | 0.73 | TUBB4A (0.37) | HCRTR1HCRTR2MAPK1NPC1RAB9A | |
| SCHEMBL10108891 | 0.73 | MAP2K3 (0.40) | MEN1KMT2AMAPK1 | |
| SCHEMBL10108980 | 0.73 | TUBB4A (0.37) | HCRTR1HCRTR2MAPK1NPC1RAB9A | |
| SCHEMBL319037 | 0.68 | TUBB4A (0.36) | ALDH1A1L3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL10109435 | 0.68 | TUBB4A (0.36) | ALDH1A1L3MBTL1MAPTKDM4EMEN1 | |
| SCHEMBL10108851 | 0.67 | NOS3 (0.44) | ALDH1A1MEN1KMT2A | |
| SCHEMBL318167 | 0.67 | NOS3 (0.44) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853578-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006088716-A1 | SUBSTITUTED TETRALINS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | ELI LILLY AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |