Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Dimethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL7858094 | 0.97 | — | — | |
| SCHEMBL124775 | 0.83 | — | — | |
| Dimethylamine SCHEMBL28037809 | 0.73 | — | — | |
| Dimethylamine SCHEMBL28080384 | 0.71 | — | — | |
| SCHEMBL9638971 | 0.65 | — | — | |
| Dimethylamine SCHEMBL1925156 | 0.63 | — | — | |
| Dimethylamine SCHEMBL5771602 | 0.60 | — | — | |
| SCHEMBL1200848 | 0.60 | ALDH1A1 (0.50) | — | |
| SCHEMBL32678 | 0.60 | — | — | |
| Dimethylformamide SCHEMBL27540006 | 0.60 | TSHR (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262199-B2 | Tyrosine kinase inhibitors | MERCK & CO., INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20060183755-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2006-08-17 | — | — | US | disclosed |
| WO-2004052286-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-06-24 | — | — | WO | disclosed |