Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542268 | 1.00 | HCAR2 (0.40) | HCAR2KDM4ETSHRKEAP1NFE2L2 | |
| SCHEMBL542266 | 1.00 | HCAR2 (0.40) | HCAR2KDM4ETSHRKEAP1NFE2L2 | |
| SCHEMBL29022487 | 0.79 | HCAR2 (0.32) | HCAR2KDM4ETSHR | |
| SCHEMBL11129144 | 0.79 | HCAR2 (0.32) | HCAR2KDM4ETSHR | |
| SCHEMBL12859161 | 0.77 | ALDH1A1 (0.35) | HCAR2KEAP1NFE2L2ALDH1A1 | |
| SCHEMBL210278 | 0.77 | — | — | |
| SCHEMBL4426723 | 0.77 | — | — | |
| SCHEMBL221900 | 0.74 | TSHR (0.35) | KDM4ETSHR | |
| SCHEMBL7030375 | 0.74 | — | — | |
| SCHEMBL7030376 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080610-A1 | UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE | University of Houston System (US) | 2016-10-19 | — | — | EP | claimed |
| US-20150168417-A1 | Universal Antigen Retrieval Compounds and Methods of Use | UNIVERSITY OF HOUSTON SYSTEM (US) | 2015-06-18 | — | — | US | claimed |
| WO-2015088667-A1 | UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE | UNIVERSITY OF HOUSTON SYSTEM (US) | 2015-06-18 | — | — | WO | claimed |
| EP-3315968-B1 | UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE | UNIV HOUSTON SYSTEM (US) | 2025-10-15 | — | — | EP | disclosed |
| US-10746637-B2 | Aldehyde scavenging agent for retrieving elements from fixed tissue | UNIVERSITY OF HOUSTON SYSTEM (US) | 2020-08-18 | — | — | US | disclosed |
| US-20190145869-A1 | METHOD OF RETRIEVING ELEMENTS FROM FIXED TISSUE | UNIVERSITY OF HOUSTON SYSTEM (US) | 2019-05-16 | — | — | US | disclosed |
| US-10203269-B2 | Method of retrieving elements from fixed tissue | UNIVERSITY OF HOUSTON SYSTEM (US) | 2019-02-12 | — | — | US | disclosed |
| EP-3315968-A1 | UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE | University of Houston System (US) | 2018-05-02 | — | — | EP | disclosed |
| US-20170184476-A1 | UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE | UNIVERSITY OF HOUSTON SYSTEM (US) | 2017-06-29 | — | — | US | disclosed |
| US-9506928-B2 | Methods for retrieving antigens using aldehyde scavenging agents | UNIVERSITY OF HOUSTON SYSTEM (US) | 2016-11-29 | — | — | US | disclosed |
| EP-3080610-A1 | UNIVERSAL ANTIGEN RETRIEVAL COMPOUNDS AND METHODS OF USE | University of Houston System (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-2477962-A1 | PRODRUGS OF GUANFACINE | Shire LLC (US) | 2012-07-25 | — | — | EP | disclosed |
| US-20120178666-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2012046062-A1 | USE OF PRODRUGS TO AVOID GI MEDIATED ADVERSE EVENTS | SHIRE, LLC (US) | 2012-04-12 | — | — | WO | disclosed |
| EP-2413937-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | Shire LLC (US) | 2012-02-08 | — | — | EP | disclosed |
| WO-2011033296-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2011-03-24 | — | — | WO | disclosed |
| US-20110065796-A1 | PRODRUGS OF GUANFACINE | SHIRE LLC (US) | 2011-03-17 | — | — | US | disclosed |
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-11-11 | — | — | US | disclosed |
| WO-2010112942-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | SHIRE LLC (US) | 2010-10-07 | — | — | WO | disclosed |
| WO-1993012138-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING HIV INFECTIONS | SCHERING CORPORATION (US) | 1993-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286186-A1 | NOVEL DICARBOXYLIC ACID LINKED AMINO ACID AND PEPTIDE PRODRUGS OF OPIOIDS AND USES THEREOF | VIP, OPRL1, OPRK1 | HCAR2 58/4885KDM4E 1873/4885TSHR 4162/4885 |
| US-20120178666-A1 | PRODRUGS OF GUANFACINE | DNPEP, VIP, GDA | HCAR2 1111/4885KDM4E 1653/4885TSHR 3582/4885 |
| US-20110065796-A1 | PRODRUGS OF GUANFACINE | DNPEP, VIP, GDA | HCAR2 1111/4885KDM4E 1653/4885TSHR 3582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.