Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5419432 | 0.99 | ALDH1A1 (0.52) | KDM4EALDH1A1SMN1; SMN2TDP1PLA2G2A | |
| SCHEMBL5415337 | 0.90 | ALDH1A1 (0.49) | KDM4EALDH1A1SMN1; SMN2TDP1PLA2G2A | |
| Hydrochloric Acid SCHEMBL5415210 | 0.89 | ALDH1A1 (0.51) | KDM4EALDH1A1SMN1; SMN2TDP1PLA2G2A | |
| SCHEMBL5430462 | 0.88 | HTR2A (0.50) | KDM4EALDH1A1SMN1; SMN2TDP1HTR2A | |
| Hydrochloric Acid SCHEMBL5411540 | 0.87 | HTR2A (0.49) | KDM4EALDH1A1SMN1; SMN2TDP1HTR2A | |
| SCHEMBL5423823 | 0.86 | CNR1 (0.40) | ALDH1A1MEN1KMT2AACHEDRD2 | |
| SCHEMBL5420593 | 0.78 | CACNB4 (0.53) | HTR2AKMT2ACYP19A1POLBHTR6 | |
| SCHEMBL5421524 | 0.78 | ALDH1A1 (0.42) | ALDH1A1HTR2ADRD2DRD4DRD3 | |
| SCHEMBL5417006 | 0.77 | OPRL1 (0.39) | KDM4ESMN1; SMN2MEN1KMT2ADRD2 | |
| Hydrochloric Acid SCHEMBL5419186 | 0.77 | CACNB4 (0.52) | HTR2AKMT2ACYP19A1POLBHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | claimed |
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | OGFRL1, OPRL1, ORMDL3 | KDM4E 4457/4885ALDH1A1 649/4885SMN1; SMN2 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.