Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5415210 | 0.99 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4ETDP1PLA2G2A | |
| SCHEMBL5422882 | 0.90 | KDM4E (0.50) | ALDH1A1SMN1; SMN2KDM4ETDP1PLA2G2A | |
| Hydrochloric Acid SCHEMBL5419432 | 0.89 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2KDM4ETDP1PLA2G2A | |
| SCHEMBL5417006 | 0.88 | OPRL1 (0.39) | SMN1; SMN2KDM4EDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL5419849 | 0.87 | OPRL1 (0.39) | ALDH1A1SMN1; SMN2KDM4ETDP1OPRL1 | |
| SCHEMBL5425389 | 0.85 | HTR2A (0.51) | ALDH1A1HTR2ADRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL5425346 | 0.84 | HTR2A (0.50) | ALDH1A1HTR2ADRD2DRD4DRD3 | |
| SCHEMBL5415247 | 0.83 | HTR2A (0.44) | HTR2ADRD2DRD4DRD3OPRM1 | |
| SCHEMBL4779433 | 0.81 | PTGDR2 (0.50) | ALDH1A1SMN1; SMN2KDM4ETDP1PTGDR2 | |
| SCHEMBL5425904 | 0.81 | MEN1 (0.47) | ALDH1A1TDP1HTR2ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | claimed |
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | GLAXOSMITHKLINE S.P.A. (IT) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197603-A1 | Substituted indole ligands for the orl-1 receptor | OGFRL1, OPRL1, ORMDL3 | ALDH1A1 649/4885SMN1; SMN2 4321/4885KDM4E 4457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.