SCHEMBL5423451

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL5419496	0.93	NPC1 (0.56)	EGFRNPC1RAB9ACNR1MEN1
	SCHEMBL5429809	0.81	SMN1; SMN2 (0.64)	NPC1RAB9AMEN1KMT2AKDM4E
	SCHEMBL5426107	0.81	SMN1; SMN2 (0.64)	NPC1RAB9AMEN1KMT2AKDM4E
	SCHEMBL30027960	0.80	EGFR (0.54)	EGFRNPC1CNR1KMT2AKDM4E
	SCHEMBL2473897	0.78	EGFR (0.51)	EGFRRAB9AKMT2AKDM4E
	SCHEMBL5438380	0.78	EGFR (0.51)	EGFRNPC1RAB9AP2RX7CNR1
	SCHEMBL1851085	0.77	CRHR1 (0.57)	EGFR
	SCHEMBL1851086	0.77	CRHR1 (0.57)	EGFR
	SCHEMBL5430952	0.77	EGFR (0.50)	EGFRP2RX7KMT2AKDM4E
	SCHEMBL2474259	0.75	EGFR (0.49)	EGFRNPC1RAB9AP2RX7MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.