Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423537 | 0.89 | HDAC1 (0.44) | USP30HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL5422216 | 0.86 | RIPK1 (0.47) | HDAC1HDAC6HDAC8RIPK1CYP3A4 | |
| SCHEMBL5426355 | 0.84 | USP30 (0.45) | USP30HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL5428076 | 0.83 | USP30 (0.63) | USP30CYP3A4MMP2MMP13MMP14 | |
| SCHEMBL30801697 | 0.82 | HDAC1 (0.45) | USP30HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL17608805 | 0.81 | HDAC1 (0.55) | USP30HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL24718689 | 0.80 | RIPK1 (0.65) | USP30HDAC1HDAC6HDAC8RIPK1 | |
| SCHEMBL3499124 | 0.78 | USP30 (0.47) | USP30HDAC1HDAC6HDAC8MMP2 | |
| Hydrochloric Acid SCHEMBL5431787 | 0.78 | MEN1 (0.48) | RIPK1CYP3A4CYP2D6CYP1A2CYP2C9 | |
| SCHEMBL5427242 | 0.78 | USP30 (0.45) | USP30HDAC1HDAC6HDAC8RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | ONO PHARMACEUTICAL CO., LTD. | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | NR3C2, CBR1, CBR3 | USP30 4584/4885HDAC1 113/4885HDAC6 266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.