Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CTSE | P14091 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423537 | 0.93 | HDAC1 (0.44) | HDAC1HDAC8HDAC6LMNAMAPT | |
| SCHEMBL17761442 | 0.89 | HDAC1 (0.54) | HDAC1HDAC8HDAC6LMNAMAPT | |
| SCHEMBL1963123 | 0.88 | HDAC1 (0.43) | HDAC1HDAC8HDAC6LMNAMAPT | |
| SCHEMBL1960250 | 0.86 | HDAC1 (0.42) | HDAC1HDAC8HDAC6LMNAMAPT | |
| SCHEMBL5423713 | 0.82 | USP30 (0.48) | HDAC1HDAC8HDAC6OPRM1OPRL1 | |
| SCHEMBL1963140 | 0.81 | AADAT (0.49) | ALDH1A1GAAL3MBTL1CYP3A4HPGD | |
| SCHEMBL22087518 | 0.80 | GRIN2B (0.48) | HDAC1HDAC8HDAC6LMNAMAPT | |
| SCHEMBL5426355 | 0.80 | USP30 (0.45) | HDAC1HDAC8HDAC6ALDH1A1TP53 | |
| SCHEMBL24399159 | 0.79 | ALDH1A1 (0.42) | HDAC1HDAC8HDAC6LMNAMAPT | |
| SCHEMBL12543528 | 0.79 | HDAC1 (0.51) | HDAC1HDAC8HDAC6LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024054919-A1 | SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF | TENACIA BIOTECHNOLOGY (HONG KONG) CO., LIMITED (CN) | 2024-03-14 | — | — | WO | disclosed |