Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 10/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 9/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL52189 | 0.79 | OGFRL1 (0.32) | OGFRL1 | |
| SCHEMBL1170226 | 0.78 | LMNA (0.36) | ALDH1A1ALOX15KDM4EMAPTMEN1 | |
| SCHEMBL12864836 | 0.76 | LMNA (0.36) | ALDH1A1ALOX15KDM4EMAPTMEN1 | |
| SCHEMBL5333442 | 0.75 | OGFRL1 (0.35) | GABRA1GABRA5ALDH1A1ALOX15KDM4E | |
| SCHEMBL5338002 | 0.75 | KDM4E (0.34) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL14064602 | 0.73 | KDM4E (0.38) | ALDH1A1ALOX15KDM4EMAPTMEN1 | |
| SCHEMBL1169995 | 0.72 | LMNA (0.35) | ALDH1A1ALOX15KDM4EMAPTMEN1 | |
| SCHEMBL13691527 | 0.71 | ALDH1A1 (0.33) | ALDH1A1ALOX15KDM4EMAPTOGFRL1 | |
| SCHEMBL6086735 | 0.70 | MAPK1 (0.36) | ALDH1A1ALOX15KDM4EMAPTMEN1 | |
| SCHEMBL6087140 | 0.70 | MAPK1 (0.40) | ALDH1A1ALOX15KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007064619-A1 | PYRIMIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-07 | — | — | WO | disclosed |
| WO-2007064619-A1 | PYRIMIDINE DERIVATIVES AS HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-07 | — | — | WO | disclosed |
| US-20070129379-A1 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-07 | — | — | US | disclosed |
| US-20070129379-A1 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-07 | — | — | US | disclosed |
| US-20070129379-A1 | HIV INTEGRASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129379-A1 | HIV INTEGRASE INHIBITORS | TYMP, POLN, IMPDH1 | GABRA1 1728/4885GABRA5 1505/4885GABRG2 2397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.