Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 4/20 | 0.38 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.38 |
| ▸ | KDM5C | P41229 | 3/20 | 0.38 |
| ▸ | KDM6B | O15054 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL28959477 | 0.94 | THRB (0.55) | THRBTSHRLMNASLC15A2POLB | |
| Succinic Acid SCHEMBL28866675 | 0.93 | THRB (0.53) | THRBTSHRLMNASLC15A2POLB | |
| SCHEMBL28001101 | 0.92 | THRB (0.53) | THRBTSHRLMNASLC15A2POLB | |
| Succinic Acid SCHEMBL28001100 | 0.92 | THRB (0.53) | THRBTSHRLMNASLC15A2POLB | |
| SCHEMBL40323 | 0.92 | THRB (0.53) | THRBTSHRLMNASLC15A2POLB | |
| Succinic Acid SCHEMBL28110365 | 0.92 | THRB (0.53) | THRBTSHRLMNASLC15A2POLB | |
| SCHEMBL75014 | 0.91 | THRB (0.55) | THRBTSHRLMNASLC15A2POLB | |
| SCHEMBL10708383 | 0.90 | THRB (0.52) | THRBTSHRLMNASLC15A2POLB | |
| Ethylene SCHEMBL19516611 | 0.90 | THRB (0.52) | THRBTSHRLMNASLC15A2POLB | |
| Ethylene SCHEMBL19516917 | 0.90 | THRB (0.52) | THRBTSHRLMNASLC15A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032590-A1 | Water base ink | TOAGOSEI CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| EP-1683842-A1 | WATER BASE INK | Toagosei Co., Ltd (JP) | 2006-07-26 | — | — | EP | disclosed |