Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 2/20 | 0.62 |
| ▸ | PTGFR | P43088 | 2/20 | 0.62 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.62 |
| ▸ | PTGIR | P43119 | 2/20 | 0.62 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.42 |
| ▸ | ITGAL | P20701 | 2/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5428042 | 1.00 | TBXA2R (0.62) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL14584117 | 0.88 | PTGER3 (0.48) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5435479 | 0.79 | TBXA2R (0.49) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5428044 | 0.75 | TBXA2R (0.45) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5430304 | 0.74 | TBXA2R (0.59) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL5430305 | 0.74 | TBXA2R (0.59) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL14584121 | 0.67 | NPC1 (0.38) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL31318330 | 0.67 | CYP1A2 (0.67) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL8517861 | 0.67 | CYP1A2 (0.67) | TBXA2RPTGFRPTGER3PTGER2PTGIR | |
| SCHEMBL31318329 | 0.67 | CYP1A2 (0.67) | TBXA2RPTGFRPTGER3PTGER2PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070043057-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-02-22 | — | — | US | disclosed |
| US-20070015771-A1 | Lonidamine analogs | THRESHOLD PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | US | disclosed |
| WO-2006015263-A2 | LONIDAMINE ANALOGS | THRESHOLD PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015771-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | TBXA2R 745/4885PTGFR 936/4885PTGER3 773/4885 |
| US-20070043057-A1 | Lonidamine analogs | LONP1, LPXN, QDPR | TBXA2R 745/4885PTGFR 936/4885PTGER3 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.