Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CTSV | O60911 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | F2 | P00734 | 6/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.43 |
| ▸ | F7 | P08709 | 6/20 | 0.43 |
| ▸ | F10 | P00742 | 5/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.43 |
| ▸ | F3 | P13726 | 1/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5883042 | 0.94 | F2 (0.48) | MEN1KMT2AMAPTALDH1A1CTSV | |
| SCHEMBL5519237 | 0.92 | MEN1 (0.48) | MEN1KMT2AMAPTALDH1A1CTSV | |
| SCHEMBL7142253 | 0.90 | F2 (0.54) | MEN1KMT2AMAPTALDH1A1CTSV | |
| SCHEMBL5512394 | 0.87 | MEN1 (0.45) | MEN1KMT2AMAPTALDH1A1CTSV | |
| SCHEMBL5417391 | 0.86 | LMNA (0.41) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL5516598 | 0.85 | SGMS2 (0.44) | MEN1KMT2AMAPTALDH1A1CTSV | |
| SCHEMBL7146245 | 0.84 | F2 (0.46) | MEN1KMT2AMAPTALDH1A1F2 | |
| SCHEMBL7146243 | 0.84 | F2 (0.46) | MEN1KMT2AMAPTALDH1A1F2 | |
| SCHEMBL7860218 | 0.83 | MEN1 (0.45) | MEN1KMT2AMAPTALDH1A1CTSV | |
| SCHEMBL5883190 | 0.81 | F2 (0.54) | MEN1KMT2AALDH1A1CTSVCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250447-B2 | Acylsulfamide inhibitors of factor VIIa | GENENTECH, INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250447-B2 | Acylsulfamide inhibitors of factor VIIa | GENENTECH, INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-20070037813-A1 | Serine Protease Inhibitors | GENENTECH, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-20070037813-A1 | Serine Protease Inhibitors | GENENTECH, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-20070037814-A1 | ACYLSULFAMIDE INHIBITORS OF FACTOR VIIa | GENENTECH, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| US-20070037814-A1 | ACYLSULFAMIDE INHIBITORS OF FACTOR VIIa | GENENTECH, INC. (US) | 2007-02-15 | — | — | US | disclosed |
| EP-1628954-A2 | ACYLSULFAMIDE INHIBITORS OF FACTOR VIIA | Genentech, Inc. (US) | 2006-03-01 | — | — | EP | disclosed |
| EP-1144373-B1 | SERINE PROTEASE INHIBITORS | GENENTECH INC (US) | 2005-10-19 | — | — | EP | disclosed |
| US-20050186198-A1 | Serine protease inhibitors | GENENTECH, INC. | 2005-08-25 | — | — | US | disclosed |
| US-6919369-B2 | Controlling blood coagulation | GENENTECH, INC. (US) | 2005-07-19 | — | — | US | disclosed |
| WO-2004113278-A2 | ACYLSULFAMIDE INHIBITORS OF FACTOR VIIA | GENENTECH, INC. (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040242585-A1 | Acylsulfamide inhibitors of factor VIIa | GENENTECH, INC. | 2004-12-02 | — | — | US | disclosed |
| US-20030212071-A1 | Serine protease inhibitors | GENENTECH, INC. | 2003-11-13 | — | — | US | disclosed |
| US-6472393-B1 | Serine protease inhibitors | GENENTECH, INC. | 2002-10-29 | — | — | US | disclosed |
| EP-1144373-A3 | SERINE PROTEASE INHIBITORS | Genentech, Inc. (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1144373-A2 | SERINE PROTEASE INHIBITORS | Genentech, Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000041531-A2 | SERINE PROTEASE INHIBITORS | GENENTECH, INC. (US) | 2000-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030212071-A1 | Serine protease inhibitors | SERPINE1, SPINT2, TFPI | MEN1 995/4885KMT2A 1165/4885MAPT 4012/4885 |
| US-20070037813-A1 | Serine Protease Inhibitors | TFPI, SPINT2, SERPINE1 | MEN1 1277/4885KMT2A 992/4885MAPT 3882/4885 |
| US-20050186198-A1 | Serine protease inhibitors | TFPI, SPINT2, SERPINE1 | MEN1 1277/4885KMT2A 992/4885MAPT 3882/4885 |
| US-20070037814-A1 | ACYLSULFAMIDE INHIBITORS OF FACTOR VIIa | TFPI, HABP2, TFPI2 | MEN1 1653/4885KMT2A 722/4885MAPT 4757/4885 |
| US-20040242585-A1 | Acylsulfamide inhibitors of factor VIIa | TFPI, TFPI2, HABP2 | MEN1 1264/4885KMT2A 830/4885MAPT 4778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.