Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429794 | 0.87 | NPC1 (0.53) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL5441331 | 0.87 | ADORA2A (0.46) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL5432213 | 0.87 | NPC1 (0.56) | KDM4EALDH1A1HSD17B10SMN1; SMN2L3MBTL1 | |
| SCHEMBL5429336 | 0.83 | KDM4E (0.61) | KDM4EALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL5426582 | 0.81 | PTGDR (0.48) | SMN1; SMN2PTGDRTSHR | |
| SCHEMBL5432244 | 0.81 | RAB9A (0.46) | KDM4EALDH1A1HSD17B10PTGDRTSHR | |
| SCHEMBL5432174 | 0.80 | RAB9A (0.50) | KDM4ESMN1; SMN2LMNAPTGDRTSHR | |
| SCHEMBL5429124 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10SMN1; SMN2L3MBTL1 | |
| SCHEMBL5435676 | 0.79 | MAPT (0.48) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL5432241 | 0.77 | RAB9A (0.48) | KDM4EALDH1A1HSD17B10SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | GRM2, GRIA2, GRM1 | KDM4E 1994/4885ALDH1A1 3149/4885HSD17B10 3305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.