Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | GALR3 | O60755 | 2/20 | 0.56 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 6/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.51 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5442987 | 0.88 | NPC1 (0.71) | NPC1GALR3NR2F2RAB9AKDM4E | |
| SCHEMBL5429104 | 0.87 | KDM4E (0.57) | NPC1GALR3NR2F2RAB9AKDM4E | |
| SCHEMBL5439725 | 0.84 | NPC1 (0.75) | NPC1GALR3NR2F2RAB9AKDM4E | |
| SCHEMBL5433514 | 0.81 | NPC1 (0.67) | NPC1GALR3NR2F2RAB9ASMN1; SMN2 | |
| SCHEMBL5435548 | 0.79 | NPC1 (0.59) | NPC1GALR3NR2F2RAB9ASMN1; SMN2 | |
| SCHEMBL1901332 | 0.78 | LMNA (0.61) | NPC1GALR3NR2F2RAB9AKDM4E | |
| SCHEMBL5123734 | 0.77 | APP (0.48) | NPC1RAB9AAPPBCHEACHE | |
| SCHEMBL5423244 | 0.77 | NPC1 (0.74) | NPC1GALR3NR2F2RAB9AKDM4E | |
| SCHEMBL5441336 | 0.77 | NPC1 (0.55) | NPC1GALR3NR2F2RAB9AAPP | |
| SCHEMBL5441331 | 0.75 | ADORA2A (0.46) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | GRM2, GRIA2, GRM1 | NPC1 3777/4885GALR3 305/4885NR2F2 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.