Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.45 |
| ▸ | CNR2 | P34972 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5429371 | 1.00 | DGAT1 (0.45) | DGAT1CNR2CSF1RPDGFRBSRC | |
| SCHEMBL7699129 | 0.88 | CSF1R (0.40) | DGAT1CNR2CSF1RPDGFRBWNT3A | |
| SCHEMBL7699131 | 0.88 | CSF1R (0.40) | DGAT1CNR2CSF1RPDGFRBWNT3A | |
| SCHEMBL7611470 | 0.86 | DGAT1 (0.44) | DGAT1CNR2CYP1A2RAB9A | |
| SCHEMBL7611481 | 0.86 | DGAT1 (0.44) | DGAT1CNR2CYP1A2RAB9A | |
| SCHEMBL7609852 | 0.79 | RAB9A (0.41) | CNR2PDGFRBCYP1A2RAB9ABRD4 | |
| SCHEMBL7609857 | 0.79 | RAB9A (0.41) | CNR2PDGFRBCYP1A2RAB9ABRD4 | |
| SCHEMBL7612701 | 0.78 | RAB9A (0.42) | DGAT1PDGFRBCYP1A2RAB9ABRD4 | |
| SCHEMBL7612677 | 0.78 | RAB9A (0.42) | DGAT1PDGFRBCYP1A2RAB9ABRD4 | |
| SCHEMBL7611753 | 0.77 | FLT3 (0.46) | CNR2CYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350747-B1 | PROTEIN SERINE/THREONINE KINASE AND PROTEIN TYROSINE KINASE ENZYME INHIBITORS; ANGIOGENESIS INHIBITORS; ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | GLAXO WELLCOME INC. | 2002-02-26 | — | — | US | claimed |
| EP-1165514-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-01-02 | — | — | EP | claimed |
| WO-2000056710-A1 | 3-(ANILINOMETHYLENE) OXINDOLES AS PROTEIN TYROSINE KINASE AND PROTEIN SERINE/THREONINE KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-09-28 | — | — | WO | claimed |
| US-20070213403-A1 | TAMOXIFEN RESPONSE IN PRE-AND POSTMENOPAUSAL BREAST CANCER PATIENTS | FORSKARPATENT I SYD AB (SE) | 2007-09-13 | — | — | US | disclosed |