Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5446715 | 0.86 | POLB (0.39) | ALDH1A1KDM4EHPGDHSD17B10F2 | |
| SCHEMBL8600231 | 0.83 | FGFR1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10FGFR1 | |
| SCHEMBL5433545 | 0.81 | KDM4E (0.46) | ALDH1A1KDM4EHPGDHSD17B10NOS3 | |
| SCHEMBL5432985 | 0.76 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDHSD17B10F2 | |
| SCHEMBL31716032 | 0.72 | PDE3B (0.48) | ALDH1A1FGFR1PDE3BPDE3AKMT2A | |
| SCHEMBL5430464 | 0.71 | KDM4E (0.50) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL16481265 | 0.70 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL20588792 | 0.70 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10FGFR1 | |
| SCHEMBL20589705 | 0.70 | KMT2A (0.42) | ALDH1A1KDM4EHPGDHSD17B10FGFR1 | |
| SCHEMBL31095270 | 0.70 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070185079-A1 | Therapeutic agents I | ASTRAZENECA AB (SE) | 2007-08-09 | — | — | US | disclosed |
| CN-1906169-A | Therapeutic agents I | ASTRAZENECA AB (SE) | 2007-01-31 | — | — | CN | disclosed |
| EP-1706384-A1 | THERAPEUTIC AGENTS I | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066132-A1 | THERAPEUTIC AGENTS I | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185079-A1 | Therapeutic agents I | HTT, GRIN2A, GRIN1 | ALDH1A1 1661/4885KDM4E 2659/4885HPGD 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.