Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27968550 | 0.82 | MKNK1 (0.71) | MKNK1JAK2KDM4EHPGDCYP1A2 | |
| SCHEMBL5427424 | 0.80 | CDC7 (0.61) | MKNK1HSD17B10KDM4EHPGDGSK3A | |
| SCHEMBL3341445 | 0.78 | GCGR (0.43) | MKNK1TNKS2PIK3C3GSK3B | |
| SCHEMBL8799713 | 0.74 | HPGD (0.51) | TNKS2HSD17B10LMNASMN1; SMN2KDM4E | |
| SCHEMBL8987066 | 0.74 | HPGD (0.51) | TNKS2HSD17B10LMNASMN1; SMN2KDM4E | |
| SCHEMBL5432014 | 0.74 | CDC7 (0.67) | GSK3AGSK3B | |
| SCHEMBL6756097 | 0.73 | TAS2R38 (0.60) | TNKS2HSD17B10LMNASMN1; SMN2KDM4E | |
| SCHEMBL8987272 | 0.73 | NOTUM (0.50) | TNKS2HSD17B10LMNASMN1; SMN2KDM4E | |
| SCHEMBL5426265 | 0.72 | MKNK1 (0.54) | MKNK1JAK2TNKS2KDM4ETP53 | |
| SCHEMBL21509969 | 0.72 | MAP2K4 (0.60) | MKNK1JAK2LMNAGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070293491-A1 | INDAZOLE COMPOUNDS AND METHODS FOR INHIBITION OF CDC7 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070293491-A1 | INDAZOLE COMPOUNDS AND METHODS FOR INHIBITION OF CDC7 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| US-20070293491-A1 | INDAZOLE COMPOUNDS AND METHODS FOR INHIBITION OF CDC7 | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| WO-2007124288-A1 | INDAZOLE COMPOUNDS AND METHODS FOR INHIBITION OF CDC7 | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293491-A1 | INDAZOLE COMPOUNDS AND METHODS FOR INHIBITION OF CDC7 | CDC7, CDC37, CDC73 | MKNK1 1096/4885JAK2 4697/4885TNKS2 1626/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.