TAS2R38 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Phenylthiourea (SCHEMBL42753)	1.00	3/20
SCHEMBL132620	1.00	3/20
SCHEMBL340780	1.00	3/20
SCHEMBL730314	0.80	3/20
SCHEMBL674953	0.76	3/20
SCHEMBL2316198	0.75	3/20
SCHEMBL3424950	0.75	3/20
SCHEMBL2875258	0.73	3/20
SCHEMBL1936559	0.70	3/20
SCHEMBL3070807	0.70	3/20
SCHEMBL1276486	0.70	3/20
SCHEMBL3073447	0.70	3/20
Methane (SCHEMBL1286316)	0.67	3/20
SCHEMBL3069527	0.64	3/20
Zinc Ion (SCHEMBL3125009)	0.64	3/20
Ethane (SCHEMBL3723781)	0.64	3/20
SCHEMBL330186	0.64	3/20
SCHEMBL1276484	0.64	3/20
SCHEMBL1455001	0.64	3/20
SCHEMBL1486771	0.64	3/20

Clinical trials — most relevant to TAS2R38 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Clinical Trial of Efficacy and Safety of Raphamin in the Treatment of Coronavirus Disease 2019 in Outpatients	PHASE3	COMPLETED
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes	PHASE2	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Glucagon-like Peptide-1 and Peptide YY	PHASE1	COMPLETED
Role of the Gut Sweet Taste Receptor in the Secretion of Satiation Peptides	PHASE1	COMPLETED
Vegetables Intake and Polymorphism TAS2R38 Gene by Healthy Adults	nan	COMPLETED
Allele-specific Expression of a Bitter Taste Receptor	nan	COMPLETED
Gustin Gene Polymorphism and 6-n-propylthiouracil (PROP) Taste	nan	COMPLETED
Astringency and Oral Health	nan	COMPLETED
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries	nan	COMPLETED
Fructose and Glucose and TAS1R2 in Type 1 Diabetes	nan	COMPLETED
NUTRACORE, Glycaemic Index and Appetite	nan	COMPLETED
Bitter Taste Receptors in Oropharynx Cancer	nan	UNKNOWN
Study of Taste Deficits	nan	COMPLETED
Genetic Variability in Taste Perception	nan	COMPLETED
Flavour Programming: Fruit and Vegetable Palatability	nan	COMPLETED
Taste Perception and Chronic Disease Risk	nan	COMPLETED
The Molecular Basis for a Broad Range of Phenotypes Related to hTAS2R38	nan	COMPLETED
Sensory Study: Taste and Tongue Biology	nan	COMPLETED
Ibuprofen Inhibits Human Sweet Taste	nan	COMPLETED
The Effect of Lactisole on the Responses to Glucose Solution	nan	UNKNOWN
A Study of the Function of Hormones Present In Taste Buds	nan	COMPLETED
Factors Affecting Salt Intake in Young Adults	nan	UNKNOWN
Impacts of Sugar-Sweetened Beverage on Body Weight	nan	COMPLETED
Sucralose and Lactisole Additions to OGTT in Humans	nan	COMPLETED
Individual Variations of Taste and Smell Perception in Alcohol Use Disorder (AUD)	nan	RECRUITING
Taste Preferences for Nutritive and Non Nutritive Sweeteners Among Children and Adults	nan	COMPLETED
CD36 and Human Fat Taste Perception	nan	COMPLETED
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents	nan	NOT_YET_RECRUITING
Sensitive Periods in Early Flavor Learning	nan	COMPLETED
The Effect of Artificial Sweeteners on Blood Glucose Response	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a TAS2R38 binder may also engage these)

Protein	Name	Similarity
Q697L6	—	1.000	Q697L6 →
Q697L2	—	1.000	Q697L2 →
Q7TQA6	—	1.000	Q7TQA6 →
Q697L4	—	1.000	Q697L4 →
Q697L3	—	1.000	Q697L3 →
Q697L5	—	1.000	Q697L5 →
Q646A5	—	1.000	Q646A5 →
Q646E9	—	1.000	Q646E9 →
TAS2R60	Taste receptor type 2 member 60	1.000	landscape →
Q646A4	—	0.999	Q646A4 →
Q646D0	—	0.999	Q646D0 →
Q646B2	—	0.999	Q646B2 →
Q9JKT2	—	0.999	Q9JKT2 →
TAS2R39	Taste receptor type 2 member 39	0.998	landscape →
Q4VHE7	—	0.998	Q4VHE7 →
Q645U7	—	0.998	Q645U7 →
Q9JKU1	—	0.998	Q9JKU1 →
P59532	—	0.998	P59532 →
Q645Y7	—	0.998	Q645Y7 →
Q645Z1	—	0.997	Q645Z1 →
Q67ES3	—	0.997	Q67ES3 →
Q9JKU0	—	0.997	Q9JKU0 →
Q646C8	—	0.997	Q646C8 →
Q7TQB9	—	0.997	Q7TQB9 →
Q645U1	—	0.997	Q645U1 →
Q645Z0	—	0.996	Q645Z0 →
Q645Y4	—	0.996	Q645Y4 →
Q646B1	—	0.996	Q646B1 →
Q646C7	—	0.995	Q646C7 →
Q646F0	—	0.995	Q646F0 →