Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.41 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
| ▸ | TGM1 | P22735 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543241 | 0.86 | MEN1 (0.42) | NPSR1MEN1KMT2AENPP2ATXN2 | |
| SCHEMBL543075 | 0.85 | DPP4 (0.42) | HPGDNPSR1MEN1KMT2AENPP2 | |
| SCHEMBL542951 | 0.85 | ENPP2 (0.54) | HPGDNPSR1MEN1KMT2AENPP2 | |
| SCHEMBL149388 | 0.83 | ENPP2 (0.55) | NPSR1ENPP2ATXN2MAPTPOLB | |
| SCHEMBL543597 | 0.82 | ENPP2 (0.52) | HPGDNPSR1MEN1KMT2ATSHR | |
| Hydrochloric Acid SCHEMBL28168579 | 0.82 | ENPP2 (0.54) | NPSR1ENPP2ATXN2MAPTPOLB | |
| SCHEMBL16825237 | 0.82 | ENPP2 (0.54) | HPGDNPSR1MEN1KMT2AENPP2 | |
| SCHEMBL542707 | 0.81 | ENPP2 (0.56) | NPSR1ENPP2ATXN2MAPTPOLB | |
| SCHEMBL543314 | 0.80 | ENPP2 (0.41) | NPSR1MEN1KMT2AENPP2ATXN2 | |
| SCHEMBL542986 | 0.79 | NPSR1 (0.44) | NPSR1MEN1KMT2AENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |