Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5430387 | 1.00 | CHRNA7 (0.44) | CHRNA7TLR7ALDH1A1MAPTMEN1 | |
| SCHEMBL5416196 | 0.91 | CHRNA7 (0.51) | CHRNA7TLR7CHRM1 | |
| Fumaric Acid SCHEMBL5410033 | 0.86 | CHRNA7 (0.47) | CHRNA7ALDH1A1MAPTMEN1LMNA | |
| Fumaric Acid SCHEMBL5410036 | 0.86 | CHRNA7 (0.47) | CHRNA7ALDH1A1MAPTMEN1LMNA | |
| Fumaric Acid SCHEMBL5412757 | 0.85 | NTMT1 (0.45) | CHRNA7MAPTMEN1LMNAKMT2A | |
| Fumaric Acid SCHEMBL5418959 | 0.85 | NTMT1 (0.45) | CHRNA7MAPTMEN1LMNAKMT2A | |
| Fumaric Acid SCHEMBL5418970 | 0.85 | NTMT1 (0.45) | CHRNA7MAPTMEN1LMNAKMT2A | |
| Fumaric Acid SCHEMBL5412745 | 0.85 | NTMT1 (0.45) | CHRNA7MAPTMEN1LMNAKMT2A | |
| SCHEMBL1459611 | 0.81 | CHRNA7 (0.51) | CHRNA7TLR7MEN1KMT2ACHRM2 | |
| SCHEMBL1459609 | 0.81 | CHRNA7 (0.51) | CHRNA7TLR7MEN1KMT2ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7309699-B2 | 3-Quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES (US) | 2007-12-18 | — | — | US | disclosed |
| US-20070275975-A1 | 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES | JI JIANGUO | 2007-11-29 | — | — | US | disclosed |
| US-20050159597-A1 | 3-Quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES | 2005-07-21 | — | — | US | disclosed |
| US-20050137203-A1 | 3-quinuclidinyl amino-substituted biaryl derivatives | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159597-A1 | 3-Quinuclidinyl amino-substituted biaryl derivatives | CHRNA7, CHRNA9, CHRNA1 | MEN1 4420/4885KMT2A 1742/4885CHRM2 35/4885 |
| US-20070275975-A1 | 3-QUINUCLIDINYL AMINO-SUBSTITUTED BIARYL DERIVATIVES | CHRNA7, CHRNA9, CHRNA1 | MEN1 4420/4885KMT2A 1742/4885CHRM2 35/4885 |
| US-20050137203-A1 | 3-quinuclidinyl amino-substituted biaryl derivatives | CHRNA9, CHRNA7, CHRNA1 | MEN1 4549/4885KMT2A 2096/4885CHRM2 34/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.