Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.38 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.38 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441447 | 0.88 | SLC2A1 (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL5800685 | 0.79 | GRIN1 (0.41) | MAPTSLC5A1SLC5A2SLC2A1POLB | |
| SCHEMBL4858756 | 0.77 | SLC2A1 (0.49) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL5434125 | 0.76 | SLC5A1 (0.40) | MAPTPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5432493 | 0.73 | SLC5A1 (0.42) | ALDH1A1SMN1; SMN2LMNAMAPTSLC5A1 | |
| SCHEMBL5797794 | 0.68 | SLC5A1 (0.46) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL4194784 | 0.66 | MAPT (0.51) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL7032876 | 0.65 | QPCT (0.56) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL13131367 | 0.65 | MAPT (0.57) | ALDH1A1KMT2ALMNAMAPTTP53 | |
| SCHEMBL5438268 | 0.65 | CRHR1 (0.35) | ALDH1A1SMN1; SMN2MAPTPDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007501828-A | — | — | 2007-02-01 | — | — | JP | claimed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | claimed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | claimed |
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |