Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | HTR6 | P50406 | 4/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | LPO | P22079 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5434125 | 0.80 | SLC5A1 (0.40) | MAPTHRH2POLBSLC5A1SLC5A2 | |
| SCHEMBL5432012 | 0.79 | ALDH1A1 (0.44) | MAPTPOLBSLC5A1SLC5A2SLC2A1 | |
| SCHEMBL5432493 | 0.75 | SLC5A1 (0.42) | MAPTSLC5A1SLC5A2HTR6 | |
| SCHEMBL5202181 | 0.73 | HRH2 (0.49) | MAPTHRH2HTR6HTR2AHTR2C | |
| SCHEMBL4857642 | 0.70 | MAPT (0.41) | MAPTHRH2POLBHTR6HTR2A | |
| SCHEMBL13131367 | 0.68 | MAPT (0.57) | MAPTPOLBHTR6LPOABCC2 | |
| SCHEMBL18509023 | 0.68 | MAPT (0.56) | MAPTPOLBLPOABCC2 | |
| SCHEMBL5801261 | 0.66 | HTR6 (0.42) | MAPTSLC5A1SLC5A2HTR6 | |
| SCHEMBL5797794 | 0.66 | SLC5A1 (0.46) | MAPTHRH2SLC5A1SLC5A2SLC2A1 | |
| SCHEMBL8685109 | 0.66 | MAPT (0.50) | MAPTPOLBSLC5A1SLC5A2LPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654253-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005019208-A1 | SUBSTITUTED 3-PYRROLIDIN-INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2005-03-03 | — | — | WO | disclosed |