Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.51 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | LIPE | Q05469 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL542677 | 0.98 | MEN1 (0.53) | MEN1KMT2AHPGDTSHRHRH3 | |
| SCHEMBL2090779 | 0.87 | ENPP2 (0.48) | MEN1KMT2AHPGDTSHRHRH3 | |
| SCHEMBL542664 | 0.86 | ENPP2 (0.52) | MEN1KMT2AHPGDHRH3ENPP2 | |
| SCHEMBL5537108 | 0.86 | ENPP2 (0.49) | MEN1KMT2AHPGDHRH3ENPP2 | |
| SCHEMBL5537103 | 0.86 | ENPP2 (0.49) | MEN1KMT2AHPGDHRH3ENPP2 | |
| SCHEMBL543132 | 0.85 | TACR1 (0.49) | MEN1KMT2AHPGDTSHRENPP2 | |
| Hydrochloric Acid SCHEMBL4681490 | 0.85 | ENPP2 (0.51) | MEN1KMT2AHPGDHRH3ENPP2 | |
| SCHEMBL5535617 | 0.83 | ENPP2 (0.48) | MEN1KMT2AHPGDHRH3ENPP2 | |
| SCHEMBL5535622 | 0.83 | ENPP2 (0.48) | MEN1KMT2AHPGDTSHRENPP2 | |
| SCHEMBL28032629 | 0.83 | KMT2A (0.64) | MEN1KMT2AHPGDENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |
| CN-101123956-A | Use of PPAR agonists to treat ruminants | PFIZER PROD INC (US) | 2008-02-13 | — | — | CN | disclosed |