Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 6/20 | 0.48 |
| ▸ | IKBKB | O14920 | 4/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 4/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.38 |
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5435591 | 0.80 | CDK2 (0.69) | SMN1; SMN2MEN1LMNACYP1A2MAPT | |
| Hydrochloric Acid SCHEMBL5425696 | 0.79 | CDK2 (0.67) | SMN1; SMN2MEN1LMNACYP1A2MAPT | |
| SCHEMBL5430039 | 0.76 | IKBKB (0.51) | IKBKBCHUK | |
| SCHEMBL5431378 | 0.74 | IKBKB (0.62) | SMN1; SMN2MEN1LMNACYP1A2MAPT | |
| SCHEMBL5718611 | 0.70 | MEN1 (0.52) | SMN1; SMN2MEN1LMNACYP1A2MAPT | |
| SCHEMBL5422645 | 0.69 | CDK1 (0.59) | SMN1; SMN2MEN1LMNACYP1A2MAPT | |
| SCHEMBL14359173 | 0.69 | SMN1; SMN2 (0.66) | SMN1; SMN2MEN1LMNACYP1A2MAPT | |
| Hydrochloric Acid SCHEMBL5432381 | 0.68 | CDK1 (0.58) | MEN1MAPTKMT2ACDK1CDK2 | |
| SCHEMBL5429356 | 0.68 | CDK2 (0.68) | CDK1CDK2IKBKBCHUK | |
| SCHEMBL5750484 | 0.67 | CDK1 (0.43) | SMN1; SMN2MEN1LMNACYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1736472-A1 | 2-AMINOPYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | NFKBIA, IKBKG, NFKB2 | SMN1; SMN2 3452/4885MEN1 4512/4885LMNA 4358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.