Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.62 |
| ▸ | CDK1 | P06493 | 6/20 | 0.52 |
| ▸ | CDK2 | P24941 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 5/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5718611 | 0.84 | MEN1 (0.52) | IKBKBCDK1CDK2MEN1LMNA | |
| SCHEMBL5427237 | 0.80 | SMARCA2 (0.53) | IKBKBCDK1CDK2MEN1LMNA | |
| SCHEMBL14028427 | 0.77 | IKBKB (1.00) | IKBKB | |
| SCHEMBL5435591 | 0.77 | CDK2 (0.69) | IKBKBCDK1CDK2MEN1LMNA | |
| Hydrochloric Acid SCHEMBL5425696 | 0.76 | CDK2 (0.67) | IKBKBCDK1CDK2MEN1LMNA | |
| SCHEMBL18013632 | 0.74 | IKBKB (0.40) | IKBKBCDK1CDK2HRH4MAP3K12 | |
| SCHEMBL5432337 | 0.74 | SMN1; SMN2 (0.51) | IKBKBCDK1CDK2MEN1LMNA | |
| SCHEMBL20861913 | 0.72 | IKBKB (0.53) | IKBKBLMNA | |
| SCHEMBL18013616 | 0.71 | HRH4 (0.39) | IKBKBHRH4MAP3K12 | |
| SCHEMBL2169029 | 0.71 | HRH4 (0.69) | CDK1CDK2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | ASTELLAS PHARMA INC. (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1736472-A1 | 2-AMINOPYRIDINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265289-A1 | 2-Aminopyrimidine Derivative | NFKBIA, IKBKG, NFKB2 | IKBKB 10/4885CDK1 477/4885CDK2 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.