Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 1/20 | 0.54 |
| ▸ | FNTB | P49356 | 1/20 | 0.54 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.54 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543243 | 0.85 | ENPP2 (0.53) | CHRM4HTR2CMEN1KMT2ANPSR1 | |
| SCHEMBL4680825 | 0.84 | MMP1 (0.51) | CHRM3HTR1AADORA3HTR2COPRK1 | |
| Hydrochloric Acid SCHEMBL4681689 | 0.84 | ENPP2 (0.53) | CHRM4HTR2CMEN1KMT2ANPSR1 | |
| SCHEMBL5542157 | 0.84 | FNTA (0.56) | FNTAFNTBPGGT1BCHRM4FFAR4 | |
| Hydrochloric Acid SCHEMBL4681152 | 0.83 | MMP1 (0.50) | CHRM3HTR1AADORA3HTR2COPRK1 | |
| SCHEMBL543007 | 0.83 | MEN1 (0.54) | TACR1CHRM3HTR2CMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4680832 | 0.82 | MEN1 (0.53) | TACR1CHRM3HTR2CMEN1KMT2A | |
| SCHEMBL5544161 | 0.81 | FNTA (0.54) | FNTAFNTBPGGT1BCHRM4ADORA3 | |
| SCHEMBL5535289 | 0.80 | FNTA (0.53) | FNTAFNTBPGGT1BCHRM4ADORA3 | |
| SCHEMBL543046 | 0.80 | ENPP2 (0.51) | FNTAFNTBPGGT1BPARP1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | disclosed |