Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | CXCL12 | P48061 | 4/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.70 |
| ▸ | MAOB | P27338 | 2/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.66 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5432805 | 1.00 | AR (1.00) | ARCXCL12MAPTSMN1; SMN2ABCG2 | |
| SCHEMBL5087995 | 0.94 | AR (1.00) | ARCXCL12MAOBCHRNA7MAOA | |
| SCHEMBL5088005 | 0.94 | AR (1.00) | ARCXCL12MAOBCHRNA7MAOA | |
| SCHEMBL5426819 | 0.87 | AR (0.79) | ARCXCL12MAPTABCG2MAOB | |
| SCHEMBL5426813 | 0.87 | AR (0.79) | ARCXCL12MAPTABCG2MAOB | |
| SCHEMBL634098 | 0.86 | PDE4A (0.82) | ARMAPTSMN1; SMN2ABCG2MAOB | |
| SCHEMBL5085637 | 0.86 | MAPT (0.75) | ARCXCL12MAPTSMN1; SMN2ABCG2 | |
| SCHEMBL634099 | 0.86 | PDE4A (0.82) | ARMAPTSMN1; SMN2ABCG2MAOB | |
| SCHEMBL26616180 | 0.86 | CXCL12 (0.81) | ARCXCL12MAPTSMN1; SMN2ABCG2 | |
| SCHEMBL5085630 | 0.86 | MAPT (0.75) | ARCXCL12MAPTSMN1; SMN2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-01-10 | — | — | US | disclosed |
| WO-2017132135-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | AR 152/4885CXCL12 2220/4885MAPT 4566/4885 |
| US-20190008797-A1 | ESTROGEN RECEPTOR ALPHA COLIGANDS, AND METHODS OF USE THEREOF | ESRRG, GPER1, ESR2 | AR 143/4885CXCL12 2622/4885MAPT 4210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.