Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.47 |
| ▸ | ATXN2 | Q99700 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TACR1 | P25103 | 5/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | ABAT | P80404 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543132 | 0.92 | TACR1 (0.49) | ENPP2ATXN2MEN1KMT2ATACR1 | |
| SCHEMBL28032625 | 0.86 | ENPP2 (0.52) | ENPP2ATXN2MEN1KMT2ATACR1 | |
| SCHEMBL543130 | 0.86 | ENPP2 (0.55) | ENPP2ATXN2MEN1KMT2ATACR1 | |
| SCHEMBL28032629 | 0.82 | KMT2A (0.64) | ENPP2ATXN2MEN1KMT2AHPGD | |
| SCHEMBL543231 | 0.81 | MEN1 (0.55) | ENPP2ATXN2MEN1KMT2ATSHR | |
| SCHEMBL542677 | 0.79 | MEN1 (0.53) | ENPP2ATXN2MEN1KMT2ATSHR | |
| SCHEMBL16093830 | 0.79 | ENPP2 (0.41) | ENPP2ATXN2MEN1KMT2ATACR1 | |
| SCHEMBL543034 | 0.78 | TACR1 (0.47) | ENPP2ATXN2TACR1TSHRCYP2D6 | |
| SCHEMBL16093646 | 0.78 | ENPP2 (0.40) | ENPP2ATXN2TACR1FFAR4MGLL | |
| SCHEMBL543075 | 0.77 | DPP4 (0.42) | ENPP2MEN1KMT2AF13A1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |