Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.55 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.55 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 3/20 | 0.54 |
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ALPL | P05186 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | ADK | P55263 | 1/20 | 0.51 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27864822 | 0.85 | FGFR1 (0.57) | AURKAMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL5383144 | 0.80 | MAP3K8 (0.42) | MAPK1MAP2K4MAPKAPK3MAPK6TTK | |
| SCHEMBL6843665 | 0.80 | MAP2K4 (0.62) | MAPK1MAP2K4MAPKAPK3MAPK6TTK | |
| SCHEMBL16777437 | 0.79 | NISCH (0.72) | KDM4EALDH1A1GAAMTORADK | |
| SCHEMBL17801025 | 0.78 | LRRK2 (0.50) | IDO1TTKLRRK2CLK4ITK | |
| SCHEMBL18977088 | 0.78 | TTK (0.75) | AURKAMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL19597646 | 0.77 | TTK (0.72) | AURKAMAPK1MAP2K4MAPKAPK3MAPK6 | |
| SCHEMBL3644191 | 0.76 | NISCH (0.74) | KDM4EALDH1A1MTORADKNISCH | |
| SCHEMBL17801028 | 0.75 | CSNK1D (0.56) | MAPK1MAP2K4MAPKAPK3MAPK6TTK | |
| SCHEMBL5636603 | 0.75 | CHEK1 (0.60) | FGFR1CDK2ITKCDK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7211594-B2 | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith | SIGNAL PHARMACEUTICALS, LLC (US) | 2007-05-01 | — | — | US | disclosed |