Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 10/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17801023 | 0.88 | LRRK2 (0.52) | LRRK2ITKMKNK1 | |
| SCHEMBL2052675 | 0.84 | CLK4 (0.57) | TDO2CLK4IDO1 | |
| SCHEMBL17801048 | 0.81 | PDPK1 (0.62) | LRRK2TDO2ITKPDPK1ADORA2A | |
| SCHEMBL5435640 | 0.78 | AURKA (0.56) | LRRK2ITKCLK4IDO1TTK | |
| SCHEMBL5383144 | 0.78 | MAP3K8 (0.42) | CLK4PDPK1MKNK1TTK | |
| SCHEMBL17696918 | 0.76 | AURKA (0.60) | LRRK2TDO2ITKCLK4ADORA2A | |
| SCHEMBL25418501 | 0.76 | PDPK1 (0.71) | LRRK2ITKPDPK1 | |
| SCHEMBL31472525 | 0.76 | PDPK1 (0.71) | LRRK2ITKPDPK1 | |
| SCHEMBL5377574 | 0.76 | CSNK1D (0.46) | MKNK1 | |
| SCHEMBL17801028 | 0.75 | CSNK1D (0.56) | LRRK2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |