Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 2/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.50 |
| ▸ | TTK | P33981 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 5/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.46 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378125 | 0.83 | CSNK1D (0.56) | CSNK1DLRRK2MAP2K4TTKMAPK8 | |
| SCHEMBL6843665 | 0.79 | MAP2K4 (0.62) | CSNK1DMAP2K4TTKMAPK8MAPK1 | |
| SCHEMBL5383144 | 0.76 | MAP3K8 (0.42) | CSNK1DMAP2K4TTKMAPK8MAPK1 | |
| SCHEMBL17801078 | 0.76 | CSNK1D (0.49) | CSNK1DLRRK2MAP2K4TTKMAPK8 | |
| SCHEMBL17801025 | 0.75 | LRRK2 (0.50) | LRRK2TTK | |
| SCHEMBL8259428 | 0.75 | MAP3K5 (0.61) | CSNK1DMAP2K4TTKMAPK8MAPK1 | |
| SCHEMBL5435640 | 0.75 | AURKA (0.56) | CSNK1DLRRK2MAP2K4TTKMAPK1 | |
| SCHEMBL8253947 | 0.74 | MAP3K5 (0.55) | CSNK1DMAP2K4TTKMAPK8MAPK1 | |
| SCHEMBL17801020 | 0.73 | FLT3 (0.56) | KDM4EALDH1A1 | |
| SCHEMBL8253769 | 0.73 | MAP3K5 (0.59) | CSNK1DMAP2K4TTKMAPK8MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | claimed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089977-A1 | SUBSTITUTED INDAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | CELGENE CORPORATION (US) | 2016-06-09 | — | — | WO | disclosed |