Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 4/20 | 0.55 |
| ▸ | ATXN2 | Q99700 | 4/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678059 | 0.88 | DPP4 (0.55) | ENPP2ATXN2GRIN2BPARP1DPP4 | |
| SCHEMBL543630 | 0.88 | ENPP2 (0.53) | ENPP2ATXN2MAPTMAPK1HTT | |
| SCHEMBL16825237 | 0.87 | ENPP2 (0.54) | ENPP2ATXN2GRIN2BDPP4PTGDR2 | |
| Hydrochloric Acid SCHEMBL4680856 | 0.87 | DPP4 (0.54) | ENPP2ATXN2GRIN2BPARP1DPP4 | |
| SCHEMBL543314 | 0.85 | ENPP2 (0.41) | ENPP2ATXN2GRIN2BPARP1DPP4 | |
| SCHEMBL543241 | 0.83 | MEN1 (0.42) | ENPP2ATXN2PARP1PTGDR2MEN1 | |
| SCHEMBL542687 | 0.82 | EPHX2 (0.45) | ENPP2ATXN2PARP1DPP4PTGDR2 | |
| SCHEMBL543666 | 0.82 | KDM4A (0.44) | ENPP2ATXN2PARP1PTGDR2 | |
| SCHEMBL543599 | 0.81 | MGLL (0.43) | ENPP2ATXN2PARP1PTGDR2MEN1 | |
| SCHEMBL148277 | 0.81 | SCN5A (0.50) | ENPP2ATXN2MAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2414330-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | claimed |
| WO-2010115491-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES AS AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-14 | — | — | WO | claimed |