Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1524326 | 0.79 | KDM4E (0.41) | — | |
| SCHEMBL21584826 | 0.75 | NPC1 (0.40) | NOS3NOS2 | |
| SCHEMBL22686367 | 0.72 | PDE10A (0.44) | — | |
| SCHEMBL5060969 | 0.72 | PDE10A (0.42) | — | |
| SCHEMBL22176343 | 0.72 | — | — | |
| SCHEMBL11611384 | 0.71 | KDM4E (0.35) | NOS3NOS2 | |
| Hydrochloric Acid SCHEMBL22164227 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL22164226 | 0.71 | — | — | |
| SCHEMBL15191540 | 0.71 | NPC1 (0.56) | — | |
| SCHEMBL15807120 | 0.70 | PIK3CG (0.58) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070027156-A1 | Crf antagonists and heterobicyclic compounds | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-02-01 | — | — | US | disclosed |
| EP-1666468-A1 | CRF ANTAGONISTS AND HETEROBICYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027156-A1 | Crf antagonists and heterobicyclic compounds | CRHR2, CRHR1, CRH | NOS3 450/4885NOS2 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.