Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 2/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31044753 | 0.87 | PIK3CD (0.41) | HTR7KDM4EALDH1A1HSD17B10PIK3CD | |
| SCHEMBL31045156 | 0.84 | GBA1 (0.41) | KDM4EALDH1A1HSD17B10PIK3CDPIK3R1 | |
| SCHEMBL5426412 | 0.81 | ALDH1A1 (0.50) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL5439734 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL20667984 | 0.79 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B10PIK3CDPIK3R1 | |
| SCHEMBL5444802 | 0.78 | ICAM1 (0.48) | KDM4EALDH1A1 | |
| SCHEMBL5423226 | 0.78 | ALDH1A1 (0.45) | KDM4EALDH1A1HSD17B10GBA1CYP2D6 | |
| SCHEMBL5435676 | 0.78 | MAPT (0.48) | KDM4EALDH1A1HSD17B10RAB9ANPC1 | |
| SCHEMBL5435776 | 0.77 | ALDH1A1 (0.54) | KDM4EALDH1A1HSD17B10GBA1RAB9A | |
| SCHEMBL5425019 | 0.77 | RAB9A (0.50) | RAB9ANPC1MAPK1CLK1GALR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | GRM2, GRIA2, GRM1 | HTR7 97/4885KDM4E 1994/4885ALDH1A1 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.