Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 20/20 | 1.00 |
| ▸ | F2 | P00734 | 5/20 | 0.74 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8353097 | 0.91 | F10 (0.84) | F10F2SLC29A1 | |
| SCHEMBL6781669 | 0.91 | F10 (1.00) | F10F2SLC29A1 | |
| SCHEMBL5447391 | 0.90 | F10 (0.81) | F10F2 | |
| SCHEMBL6785643 | 0.89 | F10 (1.00) | F10F2 | |
| SCHEMBL6494095 | 0.88 | F10 (0.83) | F10F2 | |
| SCHEMBL6792898 | 0.87 | F10 (1.00) | F10F2 | |
| SCHEMBL8354493 | 0.86 | F10 (0.87) | F10F2 | |
| SCHEMBL6782538 | 0.85 | F10 (1.00) | F10F2 | |
| SCHEMBL7088276 | 0.85 | F10 (1.00) | F10F2 | |
| SCHEMBL6493883 | 0.85 | F10 (0.84) | F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6706730-B2 | ANTICOAGULANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-16 | — | — | US | claimed |
| US-20030022916-A1 | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-01-30 | — | — | US | claimed |
| US-20070027186-A1 | SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES | BRISTOL-MYERS SQUIBB COMPANY | 2007-02-01 | — | — | US | disclosed |
| US-20070027186-A1 | SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES | BRISTOL-MYERS SQUIBB COMPANY | 2007-02-01 | — | — | US | disclosed |
| US-20070027186-A1 | SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES | BRISTOL-MYERS SQUIBB COMPANY | 2007-02-01 | — | — | US | disclosed |
| US-7153960-B2 | Synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-26 | — | — | US | disclosed |
| US-20050245566-A1 | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones | ZHOU JIACHENG | 2005-11-03 | — | — | US | disclosed |
| US-6919451-B2 | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-19 | — | — | US | disclosed |
| US-6750225-B2 | ANTICOAGULANTS | BRISTOL-MYERS SQUIBB PHARMS COMPANY | 2004-06-15 | — | — | US | disclosed |
| US-6706730-B2 | ANTICOAGULANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-16 | — | — | US | disclosed |
| US-20030181466-A1 | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-25 | — | — | US | disclosed |
| WO-2003049681-A2 | SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO [3,4-C] PYRID-2-ONES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-06-19 | — | — | WO | disclosed |
| US-20030022916-A1 | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-01-30 | — | — | US | disclosed |
| US-20020177713-A1 | 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-11-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070027186-A1 | SYNTHESIS OF 4,5-DIHYDRO-PYRAZOLO[3,4-C]PYRID-2-ONES | F2, TFPI, TFPI2 | F10 26/4885F2 1/4885SLC29A1 4125/4885 |
| US-20020177713-A1 | 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors | SERPINC1, SERPINE1, F11 | F10 31/4885F2 8/4885SLC29A1 3538/4885 |
| US-20030181466-A1 | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones | TFPI, TFPI2, F2 | F10 19/4885F2 3/4885SLC29A1 4423/4885 |
| US-20050245566-A1 | Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones | F2, TFPI, TFPI2 | F10 26/4885F2 1/4885SLC29A1 4125/4885 |
| US-20030022916-A1 | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors | SERPINC1, SERPINE1, F11 | F10 34/4885F2 9/4885SLC29A1 2146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.