Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5431132 | 0.97 | ALDH1A1 (0.38) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL503843 | 0.92 | ALDH1A1 (0.39) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL5431752 | 0.92 | ALDH1A1 (0.39) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL5425406 | 0.92 | TSHR (0.36) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL5438795 | 0.92 | ALDH1A1 (0.39) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL28024 | 0.92 | — | — | |
| SCHEMBL16878332 | 0.92 | ALDH1A1 (0.39) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL16877341 | 0.90 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| Hydrochloric Acid SCHEMBL19717587 | 0.90 | TSHR (0.39) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 | |
| SCHEMBL1961429 | 0.90 | ALDH1A1 (0.38) | ALDH1A1TSHRCYP2D6CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | ONO PHARMACEUTICAL CO., LTD. | 2007-11-29 | — | — | US | disclosed |
| EP-1683797-A1 | HETEROCYCLIC SPIRO COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-07-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275990-A1 | Heterocyclic Spiro Compound | NR3C2, CBR1, CBR3 | ALDH1A1 718/4885TSHR 254/4885CYP2D6 208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.