Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | GALR3 | O60755 | 2/20 | 0.74 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5264803 | 0.87 | NPC1 (0.57) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5429336 | 0.86 | KDM4E (0.61) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5435779 | 0.86 | NPC1 (0.98) | RAB9ANPC1GALR3NR2F2MEN1 | |
| Hydrochloric Acid SCHEMBL17456961 | 0.85 | RAB9A (1.00) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5436053 | 0.85 | NPC1 (0.55) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5423720 | 0.85 | NPC1 (0.55) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5429794 | 0.83 | NPC1 (0.53) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5264197 | 0.82 | NPC1 (0.53) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5423236 | 0.81 | RAB9A (0.73) | RAB9ANPC1GALR3NR2F2MEN1 | |
| SCHEMBL5432174 | 0.81 | RAB9A (0.50) | RAB9ANPC1GALR3NR2F2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | GRM2, GRIA2, GRM1 | RAB9A 1976/4885NPC1 3777/4885GALR3 305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.