Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | HSD17B1 | P14061 | 7/20 | 0.62 |
| ▸ | HSD17B2 | P37059 | 6/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15280046 | 0.84 | NPC1 (0.49) | HTTHSD17B1HSD17B2NPC1LMNA | |
| SCHEMBL2482877 | 0.82 | HTT (0.61) | HTTHSD17B1HSD17B2DYRK1AAPP | |
| SCHEMBL5536580 | 0.82 | HTT (1.00) | HTTHSD17B1HSD17B2DYRK1ANPC1 | |
| SCHEMBL14509024 | 0.81 | HTT (0.78) | HTTHSD17B1HSD17B2DYRK1ATP53 | |
| SCHEMBL2939270 | 0.80 | NPC1 (0.75) | DYRK1ANPC1LMNATP53CASP3 | |
| SCHEMBL11732165 | 0.79 | PPARA (0.57) | HTTNPC1LMNATP53RAB9A | |
| SCHEMBL8359106 | 0.78 | HTT (0.68) | HTTHSD17B1HSD17B2DYRK1ANPC1 | |
| SCHEMBL15280050 | 0.77 | SMN1; SMN2 (0.43) | HTTHSD17B1HSD17B2DYRK1ANPC1 | |
| SCHEMBL30192 | 0.77 | HSD17B1 (1.00) | HTTHSD17B1HSD17B2DYRK1ANPC1 | |
| SCHEMBL3357170 | 0.77 | HSD17B1 (0.47) | HTTHSD17B1HSD17B2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110571-B2 | Tyrosine kinase inhibitors; antiproliferation agents; metabolism diseases; antiallergens; central nervous system disorders; vision and skin disorders; antiarthritic agents | AVENTIS PHARMA S.A. (FR) | 2012-02-07 | — | — | US | disclosed |