Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20570564 | 0.88 | HSD17B1 (0.44) | HSD17B1HSD17B2TP53LMNANPC1 | |
| SCHEMBL544007 | 0.77 | HTT (0.69) | HSD17B1HSD17B2TP53LMNANPC1 | |
| SCHEMBL15280046 | 0.76 | NPC1 (0.49) | HSD17B1HSD17B2TP53LMNANPC1 | |
| SCHEMBL2939270 | 0.74 | NPC1 (0.75) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL20569819 | 0.73 | ALOX15 (0.41) | HSD17B1HSD17B2TP53LMNANPC1 | |
| SCHEMBL4502361 | 0.72 | WNT3A (0.42) | HSD17B1HSD17B2TP53LMNANPC1 | |
| SCHEMBL11732165 | 0.72 | PPARA (0.57) | TP53LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28904462 | 0.71 | HSD17B1 (0.48) | HSD17B1HSD17B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3242673 | 0.71 | TP53 (0.50) | TP53LMNANPC1RAB9ACASP3 | |
| SCHEMBL15280050 | 0.70 | SMN1; SMN2 (0.43) | HSD17B1HSD17B2TP53LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141164-A1 | New 1,2,4-triazine derivatives and biological applications thereof | Mutabilis (FR) | 2010-01-06 | — | — | EP | disclosed |