Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 11/20 | 0.74 |
| ▸ | WRN | Q14191 | 3/20 | 0.74 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29602870 | 0.85 | BLM (1.00) | BLMWRNKMT2AMEN1MAPT | |
| SCHEMBL20659647 | 0.85 | BLM (1.00) | BLMWRNKMT2AMEN1MAPT | |
| SCHEMBL5446510 | 0.83 | KMT2A (0.75) | BLMWRNKMT2AMEN1L3MBTL1 | |
| SCHEMBL5446263 | 0.82 | MAPT (0.63) | BLMWRNABL1KMT2AMEN1 | |
| SCHEMBL5439929 | 0.82 | MEN1 (0.59) | BLMWRNABL1KMT2AMEN1 | |
| SCHEMBL5454402 | 0.80 | BLM (0.71) | BLMWRN | |
| SCHEMBL5448580 | 0.79 | HTT (0.72) | BLMWRNABL1KMT2AMEN1 | |
| SCHEMBL5438358 | 0.78 | ABL1 (0.56) | ABL1KMT2AMEN1MAPTLMNA | |
| SCHEMBL5446202 | 0.77 | MAPT (0.59) | BLMWRNKMT2AMEN1MAPT | |
| SCHEMBL5445001 | 0.77 | BLM (0.61) | BLMWRNABL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | RAF1, ARAF, JAK1 | BLM 4089/4885WRN 3961/4885ABL1 631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.