Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | WRN | Q14191 | 1/20 | 0.56 |
| ▸ | HPN | P05981 | 1/20 | 0.56 |
| ▸ | PTPRE | P23469 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450981 | 0.86 | MAPT (0.59) | MAPTRAB9ASMN1; SMN2NPC1BLM | |
| SCHEMBL5442348 | 0.85 | HPN (0.64) | MAPTRAB9ASMN1; SMN2NPC1HPN | |
| SCHEMBL5435707 | 0.82 | HPN (0.62) | MAPTRAB9ASMN1; SMN2NPC1HPN | |
| SCHEMBL2181677 | 0.80 | RAB9A (0.69) | MAPTRAB9ASMN1; SMN2NPC1HPN | |
| SCHEMBL5447957 | 0.80 | MAPT (0.56) | MAPTRAB9ANPC1BLMHPN | |
| SCHEMBL5444646 | 0.77 | BLM (0.74) | MAPTSMN1; SMN2BLMWRNHTT | |
| SCHEMBL244007 | 0.76 | PTPRE (0.65) | MAPTRAB9ASMN1; SMN2NPC1HPN | |
| SCHEMBL3468124 | 0.76 | MAPT (0.57) | MAPTRAB9ASMN1; SMN2NPC1BLM | |
| SCHEMBL5446510 | 0.75 | KMT2A (0.75) | RAB9ANPC1BLMWRNATM | |
| SCHEMBL3466740 | 0.74 | NPC1 (0.52) | MAPTRAB9ASMN1; SMN2NPC1PTPRE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | claimed |
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | MERCK PATENT GMBH (DE) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191353-A1 | Use of thiadiazoleurea derivatives | RAF1, ARAF, JAK1 | MAPT 3983/4885RAB9A 1942/4885SMN1; SMN2 3543/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.