Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.46 |
| ▸ | GALR3 | O60755 | 2/20 | 0.43 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5436032 | 0.90 | HTT (0.67) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5427207 | 0.86 | GALR3 (0.48) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5429124 | 0.84 | KDM4E (0.49) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5438221 | 0.83 | L3MBTL1 (0.48) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5436049 | 0.83 | NPC1 (0.47) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5444805 | 0.83 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5433559 | 0.83 | NPC1 (0.47) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL5426412 | 0.83 | ALDH1A1 (0.50) | HTTSMN1; SMN2LMNAGALR3NR2F2 | |
| SCHEMBL5429794 | 0.81 | NPC1 (0.53) | HTTSMN1; SMN2LMNARXFP1GALR3 | |
| SCHEMBL31045045 | 0.80 | PIP4K2C (0.43) | PIP4K2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275984-A1 | Novel Thieno-Pyridine and Thieno-Pyrimidine Derivatives and Their Use as Positive Allosteric Modulators of Mglur2-Receptors | GRM2, GRIA2, GRM1 | HTT 2147/4885SMN1; SMN2 2102/4885LMNA 4777/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.