Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | AGER | Q15109 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7432976 | 0.98 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL19243949 | 0.88 | MKNK2 (0.48) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL7432981 | 0.84 | ALDH1A1 (0.46) | ALDH1A1TSHRL3MBTL1NPC1MAPK8 | |
| SCHEMBL16445032 | 0.84 | NAPRT (0.50) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL123523 | 0.81 | L3MBTL1 (0.64) | ALDH1A1TSHRL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL15694859 | 0.80 | KDM4E (0.52) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL1671161 | 0.80 | KDM4E (0.52) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL25270601 | 0.79 | KDM4E (0.50) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL1505205 | 0.79 | KDM4E (0.50) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 | |
| SCHEMBL3084388 | 0.79 | L3MBTL1 (0.50) | ALDH1A1TSHRKDM4ETDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | US | disclosed |
| EP-1678178-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | AstraZeneca AB (SE) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005040167-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2005-05-06 | — | — | WO | disclosed |
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| US-6699991-B2 | A ?ONE-POT? PROCESS IS DESCRIBED HEREIN FOR THE PRODUCTION OF PYRAZOLE COMPOUNDS OF GENERAL FORMULA (II) COMPRISING THE STEPS OF REACTING A COMPOUND OF GENERAL FORMULA (III) WITH AN ACYLATING AGENT IN THE PRESENCE OF A BASE AND AN OPTIONAL | PFIZER INC. | 2004-03-02 | — | — | US | disclosed |
| US-20030144530-A1 | Novel process for the preparation of pyrazoles | LAURENCE JAMES HARRIS (GB) | 2003-07-31 | — | — | US | disclosed |
| US-20020173502-A1 | Pharmaceutically active compounds | PFIZER INC | 2002-11-21 | — | — | US | disclosed |
| WO-2002072586-A1 | PYRAZOLO'4,3-D-PYRIMIDINE FOR INHIBITING CGMP PDE | PFIZER LIMITED (GB) | 2002-09-19 | — | — | WO | disclosed |
| US-20020111498-A1 | Novel process for the preparation of pyrazoles | JAMES HARRIS LAURENCE (GB) | 2002-08-15 | — | — | US | disclosed |
| EP-1222190-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | Pfizer Limited (GB) | 2002-07-17 | — | — | EP | disclosed |
| US-6407259-B1 | REACTING DIETHER COMPOUND WITH ACYLATING AGENT COMPRISING ACID ANHYDRIDE OR ACID HALIDE DERIVATIVE TO FORM PYRAZOLE DERIVATIVE | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |
| US-20020022732-A1 | Novel process for the preparation of pyrazoles | PFIZER INC. | 2002-02-21 | — | — | US | disclosed |
| EP-1176142-A1 | Process for the preparation of pyrazoles | PFIZER INC. (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2001027112-A1 | 5-(2-SUBSTITUTED-5-HETEROCYCLYLSULPHONYLPYRID-3-YL)-DIHYDROPYRAZOLO[4,3-D]PYRIMIDIN-7-ONES AS PHOSPHODIESTERASE INHIBITORS | PFIZER LIMITED (GB) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173502-A1 | Pharmaceutically active compounds | PDE5A, PDE3A, PDE3B | ALDH1A1 150/4885TSHR 3245/4885KDM4E 2357/4885 |
| US-20020022732-A1 | Novel process for the preparation of pyrazoles | NAT1, CYP2F1, CYP51A1 | ALDH1A1 399/4885TSHR 2890/4885KDM4E 2795/4885 |
| US-20030144530-A1 | Novel process for the preparation of pyrazoles | NAT1, CYP2F1, CYP51A1 | ALDH1A1 399/4885TSHR 2890/4885KDM4E 2795/4885 |
| US-20020111498-A1 | Novel process for the preparation of pyrazoles | NAT1, CYP2F1, CYP51A1 | ALDH1A1 399/4885TSHR 2890/4885KDM4E 2795/4885 |
| US-20070249648-A1 | Novel Diazaspiroalkanes and Their Use for Treatment of Ccr8 Mediated Diseases | CCR8, CCR1, CCR10 | ALDH1A1 1230/4885TSHR 3697/4885KDM4E 2994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.