Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.49 |
| ▸ | DNM2 | P50570 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17308551 | 0.85 | DNM2 (0.36) | MAPK1DNM2PTGS2KDM4EATM | |
| SCHEMBL16220909 | 0.78 | MAPK1 (0.58) | MAPK1LRRK2MAPK8MAPK9MAPK10 | |
| SCHEMBL2369879 | 0.73 | DNM2 (0.49) | DNM2PTGS2KDM4EATMUSP2 | |
| SCHEMBL1179534 | 0.72 | KDM4E (0.44) | MAPK1DNM2PTGS2KDM4EATM | |
| SCHEMBL22573058 | 0.71 | MAPK1 (0.41) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL15830033 | 0.71 | MAPK1 (0.62) | MAPK1LRRK2MAPK8MAPK9MAPK10 | |
| SCHEMBL13034557 | 0.70 | NPC1 (0.41) | MAPK1DNM2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL31051062 | 0.70 | NPC1 (0.41) | MAPK1DNM2KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17826551 | 0.69 | MAPK1 (0.43) | MAPK1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL17308604 | 0.69 | MAPK1 (0.43) | MAPK1KDM4ELRRK2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ASTRAZENECA AB (SE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259849-A1 | Azine-Carboxamides as Anti-Cancer Agents | ARAF, BRAF, RAF1 | MAPK1 443/4885DNM2 2885/4885HDAC3 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.