Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM2 | P50570 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 10/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.45 |
| ▸ | HRH1 | P35367 | 3/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276674 | 0.86 | PLK4 (0.46) | DNM2PTGS2KDM4EATMUSP2 | |
| Hydrochloric Acid SCHEMBL3780225 | 0.85 | PLK4 (0.45) | DNM2PTGS2KDM4EATMUSP2 | |
| SCHEMBL16538391 | 0.80 | WHR1 (0.54) | DNM2 | |
| SCHEMBL7357755 | 0.80 | MCHR1 (0.43) | DNM2PTGS2MCHR1ADRA2AHRH1 | |
| SCHEMBL7364277 | 0.80 | MCHR1 (0.40) | DNM2PTGS2MCHR1ADRA2AHRH1 | |
| SCHEMBL1178837 | 0.80 | MCHR1 (0.45) | DNM2PTGS2MCHR1ADRA2AHRH1 | |
| SCHEMBL30329781 | 0.79 | DNM2 (0.51) | DNM2PTGS2MCHR1ADRA2AHRH1 | |
| SCHEMBL26198161 | 0.79 | PLK4 (0.48) | KCNH2AURKB | |
| SCHEMBL7362974 | 0.78 | DNM2 (0.53) | DNM2PTGS2KDM4EATMHTT | |
| SCHEMBL11474745 | 0.77 | PDE4A (0.48) | KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545042-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | Bristol-Myers Squibb Company (US) | 2013-01-16 | — | — | EP | disclosed |
| WO-2011112191-A1 | COMPOUNDS FOR THE TREATMENT OF HEPATITIS C | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-09-15 | — | — | WO | disclosed |