Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 6/20 | 0.50 |
| ▸ | FLT4 | P35916 | 6/20 | 0.50 |
| ▸ | FLT3 | P36888 | 6/20 | 0.50 |
| ▸ | LCK | P06239 | 5/20 | 0.50 |
| ▸ | BLK | P51451 | 5/20 | 0.50 |
| ▸ | CSF1R | P07333 | 5/20 | 0.50 |
| ▸ | KIT | P10721 | 5/20 | 0.50 |
| ▸ | LYN | P07948 | 4/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 3/20 | 0.50 |
| ▸ | FRK | P42685 | 3/20 | 0.50 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5444130 | 0.87 | KDR (0.57) | KDRPDGFRBFLT1FLT4FLT3 | |
| SCHEMBL27652949 | 0.86 | KDR (0.42) | KDRPDGFRBRAB9ANPC1MAPT | |
| SCHEMBL5447368 | 0.83 | KDR (0.52) | KDRPDGFRBSMN1; SMN2PKMFLT1 | |
| SCHEMBL5449198 | 0.80 | CDK8 (0.53) | KDRFLT1FLT4FLT3LCK | |
| SCHEMBL4877916 | 0.77 | ALDH1A1 (0.41) | RAB9ANPC1MAPTSMN1; SMN2FGFR1 | |
| SCHEMBL12391453 | 0.77 | ALDH1A1 (0.49) | RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5440740 | 0.76 | RIPK1 (0.51) | KDRMAPTSMN1; SMN2FLT1AURKB | |
| SCHEMBL27673022 | 0.76 | KDR (0.41) | KDRRAB9ANPC1MAPTAURKB | |
| SCHEMBL13499154 | 0.76 | MAPK14 (0.70) | MAPK13CDK8MAPK12EPHB4PTK2 | |
| SCHEMBL5439135 | 0.76 | KDR (0.52) | KDRPDGFRBFLT1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | claimed |
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | TIE1, FLT1, FER | KDR 4/4885PDGFRB 264/4885RAB9A 818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.